The influence of the low-carbohydrate diet on AGEs production

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K00885
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Daito Bunka University
• Principal Investigator: Kaburagi Tomoko 大東文化大学, スポーツ健康科学部, 准教授 (40339479)
• Research Collaborator: OTSUKA Yuko 大東文化大学, スポーツ・健康科学部, 実験助手
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 低糖質食 / 非肥満状態 / 中鎖脂肪酸 / 脂肪細胞 / 腎臓 / 最終糖化産物

Outline of Final Research Achievements

In this study, we analyzed the impact on intake of a low-carbohydrate (LC) diet and an LC diet containing a medium-chain triglyceride (MCT-LC) on non-obese condition, using an experimental mouse model. The body weight and blood glucose levels did not differ between groups. In the LC diet, increment of renal weight, and glomerular hypertrophy and arteriolar hyalinosis were observed. In the MCT-LC diet, suppression of epididymal adipose tisseu and adipocyte area hypertrophy were observed. In the level of renal AGEs production, Nε-(carboxyethyl)lysine was lower in the MCT-LC group. Therefore, the LC diet in the non-obese condition has no antiobesity effect, indicating that has the risk of health damage is high such as a decrease in lipid metabolism and an increase in burden on the kidney and the liver.

Free Research Field

栄養学、栄養生理学、栄養生化学