Effects of elastin ingredient on the extensibility of biological soft tissues and the application of elastin to geriatric medicine

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01302
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kindai University
• Principal Investigator: Yamamoto Ei 近畿大学, 生物理工学部, 准教授 (00309270)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: バイオメカニクス / エラスチン / 皮膚 / 力学的特性 / 損傷治癒

Outline of Final Research Achievements

Collagen and Elastin are structural proteins of the dermis and are closely related to the tissue properties. It is known that ultraviolet rays decrease proteins such as elastin in the dermis. However, the biomechanical contribution of elastin to the skin properties remains unknown. The purpose of the present study was to determine whether the external medication of elastin ingredients is effective for the maintenance and improvement of the skin extensibility. Specifically, we studied the enhanced healing efficacy for ultraviolet damage by the application of an ointment involved elastin ingredients. The results obtained indicate that the stiffening or hardening of skin tissues due to the ultraviolet irradiation is presumably suppressed by the elastin application to skin tissues. Moreover, the elastin application possibly prevents the acanthosis of skin tissues due to the ultraviolet irradiation.

Free Research Field

バイオメカニクス