Suppressive effects of mild sauna stimulation on chronic kidney disease progression

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01406
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kumamoto Health Science University
• Principal Investigator: iiyama junichi 熊本保健科学大学, 保健科学部, 教授 (00398299)
• Co-Investigator(Kenkyū-buntansha): 岩下 佳弘 熊本保健科学大学, 保健科学部, 講師 (70623510)
• Co-Investigator(Renkei-kenkyūsha): KUWABARA Takashige 熊本大学, 医学部, 助教 (00393356) ; MUKOUYAMA Masashi 熊本大学, 医学部, 教授 (40270558)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 慢性腎臓病 / 温熱療法 / リハビリテーション / 反復効果 / 機能維持

Outline of Final Research Achievements

Chronic kidney disease model mice were prepared due to kidney volume reduction and interposed 4 weeks at a frequency of 5 days / week with a protocol that raised deep body temperature by about 1 - 1.5 centigrade and maintained for about 30 minutes. As a result, it was confirmed that significant protective effects of mild thermal exposure on serum creatinine and urine albumin level. As a mechanism, these were suggested that improvement of antioxidant capacity via activation of the p38 MAPK-Akt pathway and reduction of apoptosis by the expression amplification of Heat Shock Protein (HSP) 27(Am J Phys Renal phys. 2016, This article was selected APS certification and editor's picks of AJP-Renal Physiology.).

Free Research Field

リハビリテーション医学