Analysis of bone metabolism under hyperglycemia using unique type 2 diabetes model and proposal of improvement method for bone metabolism in type 2 diabetes by exercise.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01705
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kanazawa University
• Principal Investigator: KITAMURA Kei-ichiro 金沢大学, 保健学系, 教授 (80283117)
• Co-Investigator(Kenkyū-buntansha): 鈴木 信雄 金沢大学, 環日本海域環境研究センター, 教授 (60242476) ; 池亀 美華 岡山大学, 医歯薬学総合研究科, 准教授 (70282986)
• Co-Investigator(Renkei-kenkyūsha): HONDA Masao 金沢大学, 保健学系, 教授 (00272980)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖尿病 / キンギョ / 高でんぷん含有飼料 / 骨代謝 / 再生ウロコ / コラーゲン線維 / 糖化 / 運動

Outline of Final Research Achievements

We used fish, characterized by a prolonged hour hyperglycemia after starch-rich feeding, as a unique model of type 2 DM. In this model, the interfibrous crosslinking caused by production of advanced glycation end products accompanying the glycation of type I collagen fiber was increased. Furthermore, analysis of three-points bending test of glycated type I collagen fiber demonstrated that the increment of interfibrous crosslinking of collagen fibers leads to decrease of collagen fiber elasticity and of bending strength of collagen fiber. Our results indicated that the glycation of bone structure proteins bring increment of fracture risk.

Free Research Field

スポーツ健康科学