Interaction between gut microbiota and food-derived compounds for prevention and control of cardiovascular endothelial dysfunction

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K01717
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: MAWATARI Kazuaki 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (40352372)
• Co-Investigator(Kenkyū-buntansha): 下畑 隆明 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (90609687)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 腸内マイクロバイオーム / 血管内皮細胞

Outline of Final Research Achievements

Vascular endothelial cells have important roles in homeostasis of cardiovascular system. Aims of this study were to observe gut microbiota in early-stage atherosclerosis animal model, to search food-derived compounds those induce endothelium-dependent vasodilation, and to investigate effects of these compounds on gut microbiota.
Intima-thickened aorta and decrease of endothelium-dependent vasodilation were observed in high fat diet (HFD)-fed C57BL/6 mice By phylum-specific quantitative polymerase chain reaction (qPCR) for monitoring gut microbiota, HFD-fed mice had higher Firmicutes bacteria than normal diet-fed mice, but did not change Bacteroidetes bacteria. And we found that some food-derived polyphenols had activity of endothelium-dependent vasodilation, but couldn't check any effect of those on gut microbiota.

Free Research Field

栄養学