2017 Fiscal Year Final Research Report
Development of asymmetric catalyst directed to dynamic reaction field control based on bisamidine framework
| Project/Area Number |
15K05506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Rikkyo University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 不斉触媒 / 触媒設計 / 立体選択性 / DFT計算 / ビスアミジン |
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| Outline of Final Research Achievements |
To achieve high efficiency and low environmental load required for modern asymmetric catalysts, we developed an asymmetric catalyst directed to "dynamic reaction field control", in which different asymmetric reaction fields are controlled depending on catalyst preparation conditions, achieving chemoselective and stereoselective asymmetric reactions. DFT calculations clarified major factors of high selectivities based on combined-acid function and hydrogen bonding network. Specifically, chiral bisamidine ligands were developed as a key framework incorporating different catalytic functions. Selectively preparaed combined-acid catalysts or multinuclear-metal catalysts were employed to various asymmetric reactions.
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| Free Research Field |
有機合成、計算化学
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