2017 Fiscal Year Final Research Report
Abnormal transcriptional regulation in Cockayne syndrome and its effect on neuronal differentiation
| Project/Area Number |
15K06758
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The University of Tokushima (2016-2017)
Oita University (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
花田 克浩 大分大学, 医学部, 助教 (90581009)
高成 広起 徳島大学, 病院, 特任講師 (70723253)
寺林 健 大分大学, 医学部, 助教 (40452429)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | コケイン症候群 |
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| Outline of Final Research Achievements |
Cockayne syndrome is a rare autosomal recessive disease with a mutation on DNA repair genes against UV induced DNA lesions. Since Cockayne syndrome has multiple phenotypes, the pathophysiological symptoms of Cockayne syndrome patients are rather complicated. To explore the new function of Cockayne synfrome genes, we investigated the cell-differentiation experiments using SH-SY5Y cells. We success to established mild and severe Cockayne syndrome model cells using CRISPR system against CSB gene, and found the difference between mild and severe model cells upon cell differentiation inducing factors.
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| Free Research Field |
転写調節
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