Development of biomarker based on the pathogenesis of Parkinson's disease

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K06780
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Juntendo University
• Principal Investigator: SATO SHIGETO 順天堂大学, 医学部, 准教授 (00445537)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: パーキンソン病 / Parkin / ミトコンドリア / 神経変性疾患 / バイオマーカー / 認知症

Outline of Final Research Achievements

Abnormal mitochondrial accumulation leads to cell dysfunction and causes various pathological conditions such as cancer and degenerative diseases. At that time, it is speculated that the defective mitochondrial removal mechanism is triggered. Phosphorylation signals for activation of removal mechanisms, which have been clarified in in vitro systems, can be indicators of neurodegeneration. As a result of searching the brain pathology sample, it was suggested that the phosphorylation of Parkin is enhanced in the neuronal cells causing neurofibrillary tangles.

Free Research Field

神経内科

Academic Significance and Societal Importance of the Research Achievements

In vitroで明らかになりつつある不良ミトコンドリア除去機構が実際に生体内で機能しているかは不明であり今後のさらなる研究が必要である。認知症病理標本でリン酸化シグナルが亢進しているとの本研究結果は認知症の病態解明に迫るものであると同時に新たなバイオマーカーを提案するものである。