2017 Fiscal Year Final Research Report
Illumination of early stages of mitochondrial adaptation to low oxygen
| Project/Area Number |
15K07176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Fukuoka Women's University (2017)
Japan Agency for Marine-Earth Science and Technology (2015-2016) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 原生生物 |
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| Outline of Final Research Achievements |
The biochemical characteristics of an mitochondrion-related organelles (MROs) in the free-living anaerobic protist Cantina marsupialis, which represents an independent lineage in stramenopiles, were inferred based on RNA-seq data. We found transcripts for proteins known to function in one form of MROs, the hydrogenosome. In addition, MROs in C. marsupialis were also shown to share several features with canonical mitochondria, including amino acid metabolism and an "incomplete" tricarboxylic acid cycle. Transcripts for all four subunits of complex II (CII) of the electron transport chain were detected, while there was no evidence for the presence of complexes I, III, IV, or F1Fo ATPase. CII in MROs of C. marsupialis may function as succinate dehydrogenase rather than as fumarate reductase.
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| Free Research Field |
原生生物学
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