Study on light respose properties of local retinal cuircuit mediating circadian photoentrainment

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07248
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied anthropology
• Research Institution: Tokai University
• Principal Investigator: Takao Motoharu 東海大学, 情報理工学部, 教授 (90408013)
• Co-Investigator(Kenkyū-buntansha): 森田 健 福岡女子大学, 人間環境科学研究科, 教授 (20326474) ; 古賀 靖子 九州大学, 人間環境学研究院, 准教授 (60225399)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 網膜 / 概日リズム / 波長 / マウス / ヒト / 網膜電図 / 光瞳孔反射

Outline of Final Research Achievements

We performed the studies on retinal circuit mediating circadian photoentrainment in human and mouse. In a series of our study in mouse retina, we could find a novel retinogram response possibly demonstrating photorensposens of intrinsically photosensitive retinal ganglion cells (ipRGC). The behavior of this response was almost same as that of ipRGC. Neurons in suprachiasmatic nucleus responded to polychromatic light more than monochromatic light. However, it was reported that monochromatic light was more effective for puppilarry light reflex than polychromatic light in human. These facts indicate that we are required to start a detailed comparative study on retinal circuits mediating circadian photoentrainment.

Free Research Field

神経科学　生理人類学