2017 Fiscal Year Final Research Report
Peyer's patch immune cells regulates intestinal bacteria: basic research for the manipulation of intestinal bacteria by foods
| Project/Area Number |
15K07438
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Research Collaborator |
KOBAYASHI Ayano
TASAKU Yumi
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Keywords | パイエル板 / 自然リンパ球 / 腸内細菌 / IL-22 / APRIL / BAFF / IgA |
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| Outline of Final Research Achievements |
Anatomical containment of commensal bacteria in the intestinal mucosa is promoted by innate lymphoid cells (ILCs). We show that Peyer’s patch (PP) ILCs robustly produce IL-22 in the absence of exogenous stimuli. In vivo depletion of ILCs rather than T cells altered the composition of and allowed the proliferation of bacteria in PPs. Collectively, our results show that ILCs restrain commensal bacteria in the PPs.
Intestinal immunoglobulins (Igs) protect against microbes. We have investigated the roles of APRIL (TNFSF13) and BAFF (TNFSF13B) in intestinal Ig induction. PPs are, at least in part, an inductive site for Igs, including IgA. Our results demonstrate that APRIL and BAFF in vivo lowered the frequency of isotype-switched B cells in PPs. These results indicate that APRIL and BAFF paradoxically downregulate homeostatic Ig production in the intestines.
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| Free Research Field |
免疫学
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