Studies on novel insulin-sensitizing agent based on SHIP2 inhibitors

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08020
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: University of Toyama
• Principal Investigator: Toyooka Naoki 富山大学, 大学院理工学研究部(工学), 教授 (10217565)
• Research Collaborator: SASAOKA Toshiyasu ; WADA Tutomu ; GODA Hiroaki
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: インスリン抵抗性改善薬 / SHIP2 / Akt / ファーマコフォア

Outline of Final Research Achievements

Among the oral diabetic drugs, insulin-sensitizing agent is insufficient. So the development of new insulin-sensitizing agent based upon novel mechanism is urgent matter. We have investigated on the development of inhibitor of SHIP2, which shows important role for insulin resistance in the insulin signal pathway. Based on the structure of our original new insulin-sensitizing agent, we designed new pharmacophore, and acquired candidate compounds using in silico screening. Furthermore we performed the synthetic development based on the structure of candidates. The evaluations of synthetic compounds using the phosphorylation of Akt resulted in the discovery of novel SHIP2 inhibitors.

Free Research Field

有機合成化学，医薬品化学