Development of transport system of NO and H2S based on Human serum albumin

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08076
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: The University of Tokushima (2016-2017); Kumamoto University (2015)
• Principal Investigator: ISHIMA Yu 徳島大学, 大学院医歯薬学研究部(薬学系), 准教授 (00457590)
• Co-Investigator(Renkei-kenkyūsha): MARUYAMA Toru 熊本大学, 薬学部, 教授 (90423657)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ヒト血清アルブミン / 活性イオウ / 一酸化窒素 / 酸化ストレス疾 / 美白作用

Outline of Final Research Achievements

This research is based on "the complete elucidation of the endogenous transport system of physiologically active gases by HSA and its clinical application", and the generation mechanism of modifications with NO or H2S have been clarified. As a result, it was inferred that crosstalk between NO and H2S. Also, in the measurement of Cysteine persulfide, it was confirmed that an oxidized form of polysulfide was abundantly present in HSA by the newly developed measurement method, and this oxidized form of polysulfide reacts sensitively to oxidative stress It was also possible to clarify that it changes from the early stage of the disease state.

Free Research Field

薬剤学