The role of fibrinolytic system during bone repair in diabetes mic

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08195
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Kindai University
• Principal Investigator: OKADA Kiyotaka 近畿大学, 医学部, 准教授 (20185432)
• Co-Investigator(Kenkyū-buntansha): 河尾 直之 近畿大学, 医学部, 講師 (70388510) ; 梶 博史 近畿大学, 医学部, 教授 (90346255)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 骨修復 / SDF-1 / プラスミノーゲン / 骨髄幹細胞 / 組織線溶

Outline of Final Research Achievements

We previously revealed that stromal cell-derived factor-1 (SDF-1) is involved in the changes in the number of bone marrow stem cells during the bone repair process in mice. Moreover, we reported that plasminogen (Plg) deficiency delays bone repair. We investigated the roles of Plg in the changes in bone marrow stem cells during bone repair. Plg deficiency significantly blunted a decrease in the number of HSCs after bone injury in mice. Plg deficiency significantly blunted the number of SDF-1- and Osterix-double-positive cells in the endosteum around the lesion as well as mRNA levels of SDF-1 and transforming growth factor-b (TGF-b) elevated by bone injury. TGF-b signaling inhibition significantly blunted a decrease in the number of HSCs after bone injury. The present study showed that Plg is critical for the changes in bone marrow HSCs, TGF-b and SDF-1 at the damaged site during bone repair in mice.

Free Research Field

医歯薬学