Roles of neuron types and functions defining general framework for activation sequence of inspiratory neurons during inspiratory rhythmic bursts

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K08196
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Hyogo Medical University
• Principal Investigator: OKE Yoshihiko 兵庫医科大学, 医学部, 助教 (50396470)
• Co-Investigator(Kenkyū-buntansha): 三分一 史和 統計数理研究所, モデリング研究系, 准教授 (30360647)
• Research Collaborator: OKU yoshitaka
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 呼吸中枢 / preBotzinger complex / 自発的同期活動 / 神経ネットワーク / 二光子顕微鏡 / カルシウムイメージング / 抑制性ニューロン

Outline of Final Research Achievements

In this study, we investigated relationships between inspiratory neuron types and activation sequence during rhythmic bursts in the pre-Botzinger complex (preBotC). In earlier phase during each rhythmic burst, any one of inspiratory neurons of which activation patterns showed small maximum cross-correlation coefficient (maxCC) with bursting pattern were activated. On the other hand, inspiratory neurons with large maxCC were activated at/after middle phase. There was no significant differences between activation timings of excitatory and inhibitory inspiratory neurons.

Free Research Field

神経生理学

Academic Significance and Societal Importance of the Research Achievements

呼吸活動をはじめとする生命活動に必須な運動に関する神経ネットワークには、頑強性が要求される。本研究の成果は、呼吸中枢がもつ柔軟なネットワークダイナミクスの意義に迫る結果であり、機能的な神経ネットワークの新たなパラダイムを提供しており、新しい概念の神経マップの作成等を通じて脊髄損傷の再生医療などに貢献することが期待出来る。