Muscle and bone network system induced by mechanical factors

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08220
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Kindai University
• Principal Investigator: KAJI Hiroshi 近畿大学, 医学部, 教授 (90346255)
• Co-Investigator(Kenkyū-buntansha): 河尾 直之 近畿大学, 医学部, 講師 (70388510)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 骨格筋 / 骨 / メカニカルストレス / 重力 / 前庭系 / フォリスタチン

Outline of Final Research Achievements

The interactions between skeletal muscle and bone (muscle/bone relationships) have been recently noted. We investigated the influences of mechanical factors on muscle/bone relationships using the comprehensive gene analysis in mice. Our studies indicated the following conclusions: 1. Gravity change affects muscle and bone volume through the vestibular system. 2. Follistatin is involved in the effects of gravity change on muscle and bone as a humoral factor from muscle tissues. 3. Mechanical stress increases bone mineral density through the enhancement of irisin production from muscle.

Free Research Field

環境生理学