2017 Fiscal Year Final Research Report
An approach to restoring attenuated circadian physiological rhythms using artificial time cue.
| Project/Area Number |
15K08221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 体内時計 / 概日リズム / 視交叉上核 |
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| Outline of Final Research Achievements |
In this research, the circadian activity rhythms and gene expression rhythms of mice with clock or clock-related gene mutation were restored by adjusting the timing of a meal and an exercise artificially. This result showed a possibility that the meal and exercise given in the suitable time zone remedies an attenuated biological clock. Moreover,we found the abnormal pattern of a gene expression rhythm in the central biological clock of the CLOCK mutant mice, and it was suggested that attenuation of rhythms on each cell caused that phenomenon. The biological clock of CLOCK mutant mice shifts greatly by light exposure at night. Our findings advance understanding of this abnormal characteristics of biological clock in the CLOCK mutant mice.
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| Free Research Field |
時間生物学
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