Role of chymase on development and progression of organ damage induced by metabolic syndrome

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08251
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Osaka Medical College
• Principal Investigator: TAKAI Shinji 大阪医科大学, 医学研究科, 教授 (80288703)
• Co-Investigator(Renkei-kenkyūsha): KIN Tokunan 大阪医科大学, 大学院医学研究科, 講師 (90319533)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: キマーゼ / メタボリックシンドローム / 合併症 / 阻害薬 / 高血圧 / NASH / 糖尿病 / 高脂血症

Outline of Final Research Achievements

A novel non-alcoholic steatohepatitis (NASH) model was developed to clarify the role of chymase on metabolic syndrome-derived NASH in spontaneously hypertensive rats fed a high-fat and high-cholesterol diet. In the NASH model, hepatic chymase level was significantly increased, but chymase inhibitor attenuated the development and progression of NASH, resulted in a significant increase of survival rate. A novel hamster metabolic syndrome-derived NASH model was also developed in hamsters fed a high-fat and high-cholesterol diet. In this model, a significant increase of hepatic chymase was also observed.
Chymase played an important role in the development and progression of metabolic syndrome-derived NASH.

Free Research Field

医歯薬学