Biochemical and functional analysis of PLAAT family members as lipid-metabolizing enzymes

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08278
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kagawa University
• Principal Investigator: Uyama Toru 香川大学, 医学部, 助教 (30457337)
• Co-Investigator(Renkei-kenkyūsha): UEDA Natsuo 香川大学, 医学部, 教授 (20193807) ; TSUBOI Kazuhito 香川大学, 医学部, 助教 (80346642)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: PLAATファミリー / 脂質代謝酵素 / ペルオキシソーム / N-アシル-ホスファチジルエタノールアミン / N-アシルエタノールアミン / cPLA2ε / ホスファチジルセリン

Outline of Final Research Achievements

Phospholipase A/acyltransferase family members consist of five proteins (PLAAT-1-5) and possess lipid-metabolizing activities. In this study, we examined the role of PLAAT-3 in peroxisome metabolism. We also analyzed the N-acyltransferase involved in the biosynthesis of the rare phospholipid species, N-acylphosphatidylethanolamine.

Free Research Field

脂質生化学