2017 Fiscal Year Final Research Report
Role of fatty acid binding protein 4 (FABP4) as an exogenous ligand, on growth of prostate cancer cells
| Project/Area Number |
15K08403
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
高橋 徹行 武蔵野大学, 付置研究所, 講師 (00403692)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 前立腺癌 / 肥満 / FABP4 / LSR |
|---|
| Outline of Final Research Achievements |
Epidemiologically, obesity is known to be associated with prostate cancer development. In order to investigate its mechanism, we focused on Fatty acid binding protein 4 (FABP 4) which is one of adipokines. In this study, it was revealed that FABP4 is involved in activation of PI3K / Akt pathway and cell proliferation by interaction with lipolysis stimulated lipoprotein receptor present on the cell membrane of prostate cancer cells.
|
| Free Research Field |
癌の浸潤・転移
|
