Is serum thrombospondin-2 a predictor for cardiac dysfunction in a general population?

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08717
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kurume University
• Principal Investigator: Hisashi Adachi 久留米大学, 医学部, 教授 (40212518)
• Co-Investigator(Kenkyū-buntansha): 植田 晋一郎 久留米大学, 医学部, 助教 (00412502) ; 堀 賢介 久留米大学, 医学部, 助教 (50647815)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: thrombospondin-2 / coronary risk factor / health check-up / epidemiology

Outline of Final Research Achievements

We measured thrombospondin (TSP)-2 for 446 subjects in Uku town in 2013 and 2014. TSP-2 is associated with FPG, insulin, HOMA index, eGFR (inversely), hs-CRP, past history of CHD and NT-proBNP. With the stepwise regression analysis, TSP-2 is independently associated with HOMA index, hs-CRP, past history of CHD and NT- proBNP. TSP-2 is strongly associated with cardiovascular-related risk factors even in healthy subjects. Using these 446 subjects, we are performing to follow-up them, and continue a prospective study to clarify our hypothesis "Is serum thrombospondin-2 a predictor for cardiac dysfunction in a general population?".

Free Research Field

循環器疾患の予防、疫学