Effects of fetal and early childhood environment on childhood obesity and adult non-communicable diseases from the epidemiological view

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08731
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Aichi Medical University (2016-2017); University of Yamanashi (2015)
• Principal Investigator: Suzuki Kohta 愛知医科大学, 医学部, 教授 (90402081)
• Co-Investigator(Kenkyū-buntansha): 平田 修司 山梨大学, 大学院総合研究部, 教授 (00228785) ; 山縣 然太朗 山梨大学, 大学院総合研究部, 教授 (10210337)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: DOHaD説 / 疫学 / コホート研究 / 母子保健 / マルチレベル解析

Outline of Final Research Achievements

Recently, it has been suggested that fetal and early childhood environment might be important for later health status by the concept of “Developmental Origin of Health and Diseases”. Thus, first, we described the trajectories of gestational weight gain (GWG) by using more than 10000 prenatal check-up data. It has been suggested that GWG after the 2nd trimester seemed almost linear and GWG might be increased by maternal smoking during pregnancy. Moreover, we described the trajectory of fetal growth. Fetal growth during the 3rd trimester might be decreased by maternal smoking during pregnancy. Next, the effect of maternal smoking during pregnancy on childhood growth seemed more apparent among children in the 2nd quartile of birth weight. Finally, we established the new cohort study in Gobo city (Wakayama Pref.) to describe the maternal smoking status from pregnancy registration to early childhood medical check-ups for their children.

Free Research Field

疫学、公衆衛生学