2018 Fiscal Year Final Research Report
Screening for the risk factors of lifestyle-related diseases including fetus-infancy information in addition to the genetic and environmental factors
| Project/Area Number |
15K08778
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Hygiene and public health
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
UEMURA Hirokazu 徳島大学, 大学院医歯薬学研究部(医学域), 准教授 (50346590)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
釜野 桜子 徳島大学, 大学院医歯薬学研究部(医学域), 助教 (00612574)
山口 美輪 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (20721674)
有澤 孝吉 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (30203384)
|
|---|
| Project Period (FY) |
2015-04-01 – 2019-03-31
|
| Keywords | 糖尿病 / インスリン抵抗性 / 慢性炎症 / 動脈スティフネス / 脈派伝播速度 / 大豆イソフラボン / メタボリック症候群 / 身体活動 |
|---|
| Outline of Final Research Achievements |
An alternating decision tree algorithm, a powerful classification algorithm from data mining, revealed that systemic inflammation was proportionally associated with increased prevalence of type 2 diabetes even after adjusting for body mass index, especially in subjects without a family history of diabetes. Elevated systemic inflammation is dose-dependently associated with increased insulin resistance, and concomitant obesity and elevated systemic inflammation may synergistically contribute to increased insulin resistance in a Japanese population. Greater consumption of fermented soy products and soy isoflavone was associated with reduced arterial stiffness, independent of systemic inflammation, in Japanese men. Higher daily life activity and higher moderate intensity exercise may be independently associated with a lower risk of metabolic syndrome in Japanese adults, and higher daily life activity was particularly associated with reduced prevalence for low HDL cholesterol.
|
| Free Research Field |
疫学
|
| Academic Significance and Societal Importance of the Research Achievements |
生活習慣病の発症には多くの遺伝要因や生活習慣要因が関わっており、大規模調査では取り扱うデータ量も膨大となる。機械学習の医療データへの適応はまだ少ないが、コホートデータにalternating decision tree アルゴリズムを用いた成果を海外学術雑誌に掲載できたこと、また、日本の伝統的な食事が見直される中、発酵大豆食品や大豆イソフラボンの摂取が血管壁の弾力性の保持に有用である可能性が示されたことは社会的に意義がある。さらに、血中HDLコレステロール低下の予防因子はあまり明らかでないが、日常生活活動を増やすことが予防につながる可能性が示されたことは実現可能性の点からも意義がある。
|
