Search for new biomarkers and Survey of cerebrovascular disease due to cancer-related hypercoagulability

2021 Fiscal Year Final Research Report

• Project/Area Number: 15K08915
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Osaka University
• Principal Investigator: Sakaguchi Manabu 大阪大学, 医学系研究科, 招へい教員 (70432474)
• Project Period (FY): 2015-04-01 – 2022-03-31
• Keywords: がん / 脳梗塞 / 多施設共同前向き観察研究

Outline of Final Research Achievements

We conducted a multicenter prospective observational study of active cancer and ischemic stroke at nine stroke centers in Japan. Eligible patients were followed up to 1 year after ischemic stroke. During the study periods, 135 patients who had active cancer and ischemic stroke were enrolled (median age, 75 years; 52 [38.5%] were female). The most common type of cancer was lung cancer, and 77 (57.0%) patients had and advanced cancer. Analyses showed that the survival probability after ischemic stroke was 54.1% at 1 year. The cumulative incidence of recurrent stroke and major bleeding were 10.3% and 9.0%, respectively.

Free Research Field

脳血管障害

Academic Significance and Societal Importance of the Research Achievements

本研究は、がん合併脳梗塞の実態調査を多施設共同前向き観察研究で行なった、我が国初めての研究である。がん患者が高齢化しており、がん患者の併存症管理の重要性が高まっている。その中でも、がんと脳卒中は共通のリスク因子があり、重要な疾患である。活動性がんを有するがん患者が脳梗塞を発症した場合、半数以上でステージ３以上の進行がんであること、１年後の生存率が54.1％であることは、今後のがん診療・脳卒中診療を行う上で、重要な知見となる。