Ex Vivo Expanded Erythroblast-Transplantation versus autologous bone marrow mononuclear cell implantation for patient with critical limb ischemia

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09117
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Niigata University
• Principal Investigator: Ozawa Takuya 新潟大学, 医歯学系, 講師 (70467075)
• Co-Investigator(Kenkyū-buntansha): 柳川 貴央 新潟大学, 医歯学総合病院, 特任助教 (10625586) ; 森山 雅人 新潟大学, 医歯学系, 准教授 (30598131) ; 増子 正義 新潟大学, 医歯学総合病院, 准教授 (70397115) ; 須田 将吉 新潟大学, 医歯学総合病院, 医員 (70714509)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 臨床心血管病態学 / 血管再生 / 赤芽球 / 細胞療法 / 体外増幅

Outline of Final Research Achievements

We investigated the safety and efficacy of angiogenic cell therapy by implantation of ex vivo expanded immature erythroblasts cultured from autologous bone marrow cells(EVEETA) for patient with critical limb ischemia comparing to implantation of bone marrow mononuclear cells(BMI). Freedom from major/minor amputation rate was significantly higher in EVEETA than BMI.

Free Research Field

医歯学系