Quantitative assessment of extra-cellar matrix in diseased lung, during regeneration, hyperinflation, and development of emphysema

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09172
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: Sato Susumu 京都大学, 医学研究科, 助教 (40378691)
• Co-Investigator(Kenkyū-buntansha): 陳 豊史 京都大学, 医学研究科, 講師 (00452334)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 細胞外マトリックス / 肺気腫 / メカニクス

Outline of Final Research Achievements

Elastase induced lung injury (emphysematous lesion) in model mouse represent significant relationship with respiratory mechanical property measured by forced oscillation technique. In addition, cranial-caudal heterogeneity of emphysema showed significant and independent association with heterogeneity of elastane (SD of H). These associations were preserved in acute model (3 weeks after injury) and chronic model (13 weeks after injury). However, in chronic model, airway resistance (Raw) also showed significant association and may suggest difference of structure-function relationship in development of emphysema.
Dose dependent effect of elastane in development of emphysema showed ceiling-effect in chronic model.

Free Research Field

呼吸器内科学