Developing novel lung cancer therapy targetting cancer cell intrinsic ligands

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09220
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Osaka University
• Principal Investigator: Kijima Takashi 大阪大学, 医学系研究科, 招へい教授 (90372614)
• Co-Investigator(Kenkyū-buntansha): 南 俊行 大阪大学, 医学系研究科, 特任助教(常勤) (00705113) ; 小山 正平 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (80767559) ; 長 彰翁 大阪大学, 医学部附属病院, 医員 (20751390) ; 森村 治 大阪大学, 医学部附属病院, 医員 (80743765) ; 内藤 祐二朗 大阪大学, 医学部附属病院, 医員 (30800982)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肺癌 / 癌微小環境 / 内在性リガンド

Outline of Final Research Achievements

In this study, we evaluated how tumor-associated vesicles like apoptotic bodies released after chemotherapies can modulate tumor microenvironment in terms of sensitivity to subsequent chemotherapies. We found that a specific type of chemotherapy can induce TLR2 ligand, which modulate inflammatory status in lung cancer microenvironment and reduce the sensitivity for the subsequent chemotherapies.

Free Research Field

肺癌