2017 Fiscal Year Final Research Report
Progressive kidney disease and inflammation
| Project/Area Number |
15K09251
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
和田 隆志 金沢大学, 医学系, 教授 (40334784)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 腎臓内科学 / 感染症学 |
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| Outline of Final Research Achievements |
Chronic inflammation contributes to the progression of kidney disease. We found the novel macrophage regulator molecule, which is involved in progressive kidney injury in mice model. Moreover, Apoptosis inhibitor of macrophage (AIM), which is secreted by macrophage, was detected in various kinds of human kidney disease in kidney biopsy specimen. The deposition of AIM was associated with the increase of proteinuria and the decline of eGFR. These results showed the important role of macrophage in progressive kidney disease both in mouse and human.
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| Free Research Field |
腎臓内科学
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