Sirt1 and NMN mediate the tubular-PEC crosstalk.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09272
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Keio University
• Principal Investigator: Hasegawa Kazuhiro 慶應義塾大学, 医学部(信濃町), 助教 (30424162)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 近位尿細管

Outline of Final Research Achievements

We have recently disclosed that tubular epithelial cells affect the podocyte epigenome though nicotinic acid metabolism in diabetic nephropathy (DN), and we have named this relationship "proximal tubule-podocyte communication". First, we elucidated the details of proximal tubule-podocyte communication. Second, we identified how Sirt1 regulates albuminuria. This means that repeated high glucose stress triggers the initial changes in proximal tubules, which lead to the epigenetically irreversible glomerular damages. Proximal tubular Sirt1 overexpression can rescue these changes. Third, we identified a mediator connecting this communication, nicotinamide mononucleotide (NMN).

Free Research Field

腎臓内科学