2017 Fiscal Year Final Research Report
Role of TLR/BAFF/APRIL in the pathogenesis of IgA nephropathy
| Project/Area Number |
15K09274
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
SUZUKI Yusuke
MAKITA Yuko
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | IgA腎症 / 糖鎖異常IgA1 / 免疫複合体 / TLR / APRIL / BAFF |
|---|
| Outline of Final Research Achievements |
TLR9 activation induced mesangioproliferative glomerulonephritis accompanied by mesangial deposition of IgA, and C3. Serum levels of Gd-IgA, IgG-IgA immune complexes and APRIL are overproduced by TLR9 activation. Serum levels of APRIL significantly correlated with serum level of Gd-IgA and IgG-IgA immune complexes. The activation of TLR9 induced production of IL-6, and IL-6 stimulation induced overexpression of APRIL in splenocytes. In IgA nephropathy, TLR9 activation enhanced Gd-IgA1 production through overexpression of IL-6 and APRIL.
|
| Free Research Field |
IgA腎症
|
