2017 Fiscal Year Final Research Report
Evaluation of renal plasma flow and glomerular filtration rate in the patients with sepsis
| Project/Area Number |
15K09281
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
湯澤 由紀夫 藤田保健衛生大学, 医学部, 教授 (00191479)
外山 宏 藤田保健衛生大学, 医学部, 教授 (90247643)
市原 隆 藤田保健衛生大学, 保健学研究科, 教授 (90527748)
小出 滋久 藤田保健衛生大学, 医学部, 講師 (40760913)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 糸球体濾過量 / 腎血漿流量 / ダイナミックCT |
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| Outline of Final Research Achievements |
We established a method for the measurement of effective renal plasma flow (CT - ERPF) and glomerular filtration rate (CT - GFR) by dynamic CT imaging. In 16 renal transplant donors, CT-GFR and inulin clearance were highly correlated with r = 0.76 and p = 0.00063. CT-ERPF and CT-GFR were measured separately in the renal cortical surface layer and in the deep layer. In 13 renal transplant donors, CT-ERPF was 2.61±0.87ｍL/min/cm2 in the deep layer and 2.61±0.88ｍL/min/cm2 in the surface layer. CT-GFR was 0.63±0.15ｍL/min/cm2 in the deep layer and 0.66±0.14 in the surface layer. In the sepsis patient, CT-ERPF was 0.615 mL/min/cm2 in the deep layer and 0.650 mL/min/cm2 in the surface layer. CT-GFR was 0.452 mL/ min/cm2 in the deep layer and 0.461 mL/min/cm2 in the surface layer. In this study,CT - GFR / CT - ERPF was higher in the septic patient than in the kidney transplant donors. We aim for practical application of this method.
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| Free Research Field |
腎臓内科
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