PD-related peritonitis, especially fungal peritonitis, and peritoneal injuries associated with impairment of the complement system

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09288
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: Mizuno Masashi 名古屋大学, 医学系研究科, 寄附講座教授 (20303638)
• Co-Investigator(Kenkyū-buntansha): 鈴木 康弘 名古屋大学, 医学系研究科, 寄附講座講師 (20584676) ; 坂田 史子 名古屋大学, 医学系研究科, 特任助教 (20726484) ; 伊藤 恭彦 愛知医科大学, 医学部, 教授 (60402632)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 人工透析学 / 腹膜透析 / 補体活性化 / 補体制御 / 腹膜障害

Outline of Final Research Achievements

Peritoneal injury is an important factor to prevent long-term peritoneal dialysis (PD), possibly following a progression of encapsulating peritoneal sclerosis (EPS) which has poor prognosis. To clarify the complement (C)-related mechanisms of development of peritoneal injuries, we have approached as an aspect of the C activation system. In the present study, we showed changes of membrane C regulators (CReg)’ expression in peritoneal mesothelium. A C activation product, we showed that sC5b-9, was useful as a surrogate maker to predict prognosis of PD-related peritonitis because peritonitis is another reason of PD withdrawal. We also developed a new peritonitis animal model to investigate mechanisms of EPS.

Free Research Field

内科学