An investigation for optimal signal crosstalk in heparin binding growth factor promoting neurogenesis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09326
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Juntendo University
• Principal Investigator: Arikawa-Hirasawa Eri 順天堂大学, 医学(系)研究科(研究院), 教授 (50245718)
• Co-Investigator(Renkei-kenkyūsha): KIMATA Koji 愛知医科大学, 大学院医学研究科, 特任教授 (10022641) ; SASAKI Takako 大分大学, 大学院医学研究科, 助教 (30133193) ; KEREVER Aurelien 順天堂大学, 大学院医学研究科, 助教 (70623594)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ヘパラン硫酸プロテオグリカン / ヘパリン親和性増殖因子 / 成体神経新生 / 糖鎖 / 硫酸化 / 細胞外マトリックス

Outline of Final Research Achievements

Heparin affinity growth factor group is expected as one of therapeutic targets for neurodegenerative diseases typified by hepatocyte growth factor (HGF), but there are many problems to be solved to realize clinical application. In this study, we aim to develop an adult neurogenesis control method by targeting heparan sulfate proteoglycan (HSPG) in the extracellular matrix and optimizing GF activity localization and "signal crosstalk" with other heparin affinity growth factors. Modification of sugar chain was considered important for preparation of heparin affinity growth factor / heparan sulfate chain typified by FGF - 2 which controls adult neurogenesis. We proceeded with disaccharide analysis using samples of the adventitial neurogenic region, the subventricular zone and the hippocampus, and showed characteristics of sugar chain modification such as sulfation.

Free Research Field

神経内科