2017 Fiscal Year Final Research Report
The search for a biomarker for multiple system atrophy
| Project/Area Number |
15K09334
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Mitsui Jun 東京大学, 医学部附属病院, 特任准教授 (70579862)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 多系統萎縮症 / 神経変性疾患 / バイオマーカー / コエンザイムQ10 / 酸化ストレス / 電子伝達系 / iPS細胞 |
|---|
| Outline of Final Research Achievements |
We compared the levels of plasma CoQ10 in patients with MSA with those in age-, sex-, and COQ2 genotype-matched controls and found decreased levels of plasma CoQ10 in patients with MSA regardless of the COQ2 genotype.
We found functional deficiency of mitochondrial respiration and anti-oxidative system in induced pluripotent stem cell (iPSC)-derived neurons from an MSA patient with the compound heterozygous COQ2 mutations. We also found an increase in apoptosis of iPSC-derived neurons from MSA patients.
These findings support a hypothesis that supplementation with CoQ10 is beneficial for patients with MSA.
|
| Free Research Field |
神経変性疾患
|
