Significance of angiogenesis inhibitor THBS1 in white adipocyte browning

2019 Fiscal Year Final Research Report

• Project/Area Number: 15K09386
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kyoto University
• Principal Investigator: INOUE MAYUMI 京都大学, 医学研究科, 特定教授 (80512079)
• Project Period (FY): 2015-04-01 – 2020-03-31
• Keywords: 肥満 / ECM / THBS1 / 褐色脂肪細胞

Outline of Final Research Achievements

In recent years, brown adipocytes-like tissue is also present in adults, and its effect on the energy consumption of the whole body has been suggested. We found that brown cell-like changes were seen in the white adipose tissue of KO mice of angiogenesis inhibitor THBS1. Furthermore, mitochondrial respiration in adipocytes was elevated in THBS1KO or KD cells. THBS1KO mice capillaries in adipose tissue was increased compared to WT mice. These results strongly suggest the browning change of white adipocytes. In addition, we began to verify based on clinical data obtained by the examination to demonstrate the results obtained in these animal experiments in humans.

Free Research Field

代謝内科学

Academic Significance and Societal Importance of the Research Achievements

食事量が同じでも、太る人と太らない人がいる。また、太っていてもメタボリックシンドロームになる人と、ならない人がいる。それらの疑問の一つの答えの解明、また、適正体重の維持、また例え太っても致死的な疾患に至らないための方法の一つを解明しつつある。また主に動物で証明してきた事柄をヒトで実証することによりさらに本質的な病態の解明にせまる。