Analysis and clinical application of BMP in the regulation of H-P-O axis.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09434
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Okayama University
• Principal Investigator: Otsuka Fumio 岡山大学, 医歯薬学総合研究科, 教授 (40362967)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: 卵巣 / 下垂体 / 視床下部 / 生殖内分泌 / 骨形成蛋白 / ステロイド合成

Outline of Final Research Achievements

Female infertility is an urgent issue to be solved; however, the detailed regulatory mechanism of the reproductive axis composed of hypothalamus-pituitary-ovary (HPO) has yet to be fully clarified. We investigated the physiological and endocrinological significance of bone morphogenetic protein (BMP) molecules in the ovarian follicles as well as in the HPO axis. Here, we revealed that the BMP system plays critical roles as a intracellular communicator in the ovarian follicle and that it also works as a fine modulator with various circadian regulators in the HPO axis. These findings would be informative for the clinical application of BMPs for diagnosis and treatment of female infertility.

Free Research Field

生殖内分泌