2017 Fiscal Year Final Research Report
Clarifying the pathogenesis of ABC-DLBCL in a mouse model
| Project/Area Number |
15K09474
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IWAI Kazuhiro 京都大学, 大学院医学研究科 細胞機能制御学講座, 教授 (60252459)
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| Research Collaborator |
JO Tomoyasu 京都大学, 大学院医学研究科血液・腫瘍内科学
ARIMA Hiroshi 京都大学, 大学院医学研究科血液・腫瘍内科学
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 悪性リンパ腫 / マウスモデル |
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| Outline of Final Research Achievements |
To clarify the pathogenesis of ABC－type diffuse large B-cell lymphoma (DLBCL), we generated a mouse lymphoma model by crossing gene-engeneered mice carrying HOIP and mutant MyD88 transgenes. We have found how these genes cooperate with each other during lymphomagenesis.
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| Free Research Field |
血液腫瘍学
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