Regulations of inflammatory responses induced by Chlamydia

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09561
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Hokkaido University
• Principal Investigator: Matsuo Junji 北海道大学, 保健科学研究院, 講師 (50359486)
• Co-Investigator(Kenkyū-buntansha): 中村 眞二 順天堂大学, 医学(系)研究科(研究院), 助教 (40207882) ; 山口 博之 北海道大学, 保健科学研究院, 教授 (40221650)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: クラミジア / 炎症 / サイトカイン / アポトーシス

Outline of Final Research Achievements

To understand host inflammatory responses induced by Chlamydia, we tried to identify a novel receptor of host cells and chlamydial factors, which are conserved in the Chlamydiales. As a result, a non-TLR receptor and a heat-labile chlamydial factor may be involved in host inflammatory responses. In addition, the responses were enhanced in low oxygen environments. On the other hands, host caspase-3 dynamics was revealed using a cyclic fire luciferase probe. We also showed that miRNA regulation may be involved in the host inflammatory responses induced by Chlamydia.

Free Research Field

感染症学