Infectious mechanism of avian influenza viruses based on cellular endosomal pH

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09576
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Daidoji Tomo 京都府立医科大学, 医学(系)研究科(研究院), 講師 (80432433)
• Co-Investigator(Kenkyū-buntansha): 渡邊 洋平 京都府立医科大学, 医学(系)研究科(研究院), 講師 (50452462)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 鳥インフルエンザウイルス

Outline of Final Research Achievements

The purpose of this study was to clarify the mechanism of avian influenza viruses to infect human airway epithelial cells, from aspects of both the virus genome and host cells. Viral infectivity in human airway epithelial cell clones was different between currently circulating avian influenza virus isolated from humans and the virus from birds. This distinct infectivity was determined by the specific amino acid sequences, located in individual genomes of the viruses from human and birds. Next, we assessed the infectivity of avian influenza viruses in differentiated human airway epithelial cell clones. The difference in viral infectivity in differentiated human airway epithelial cell clones may be associated with the difference in cell differentiation.

Free Research Field

ウイルス学