2017 Fiscal Year Final Research Report
Recovery of thymus function using cultured mast cells: prevention of lethal chronic graft-versus-host disease
| Project/Area Number |
15K09643
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Research Collaborator |
ARAKI Raita
KURODA Rie
MASE Shintaro
MAEBA Hideaki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 慢性GVHD / 肥満細胞 |
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| Outline of Final Research Achievements |
Refractory hematological malignancies have been cured by the progress of hematopoietic stem cell transplantation, however graft-versus-host disease (GVHD) is still an obstacle. We have studied the pathophysiology of GVHD using a rodent model to develop new treatments, especially focusing in chronic GVHD probably caused by functional impairments of thymus. In this study, we have indicated that host-typed mast cells are involved in the recovery of thymus function using mast cell deficient mice.
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| Free Research Field |
造血幹細胞移植
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