Basic research for "RSV pregnant women vaccine" by clinical isolates aimed at overcoming RSV infection

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09658
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Fukushima Medical University
• Principal Investigator: Hashimoto Koichi 福島県立医科大学, 医学部, 准教授 (50322342)
• Co-Investigator(Kenkyū-buntansha): 細矢 光亮 福島県立医科大学, 医学部, 教授 (80192318) ; 錫谷 達夫 福島県立医科大学, 医学部, 教授 (40196895) ; 橋本 優子 福島県立医科大学, 医学部, 教授 (60305357) ; 川崎 幸彦 福島県立医科大学, 医学部, 准教授 (00305369)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: RSV / ワクチン / 中和抗体価 / 臨床分離株 / マウス / 遺伝子型

Outline of Final Research Achievements

Respiratory syncytial virus (RSV) infection is a major disease burden worldwide and vaccine development is desired. In this study, basic research leading to "pregnant women vaccine", which is the closest to practical application, was carried out by mice infection experiments using RSV clinical isolates and measurment of anti-RSV neutralizing antibody titers in adult sera. From the results of the study, it was suggested that choice of antigen recognition site that can lead to neutralizing antibodies in subgroups A and B at the time of vaccine preparation and also capable of coping with genotype change is important.

Free Research Field

臨床ウイルス学