2017 Fiscal Year Final Research Report
Investigation of mucosal immune system in relation to pediatric onset gastrointestinal diseases.
| Project/Area Number |
15K09699
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
清水 俊明 順天堂大学, 医学部, 教授 (30260889)
藤井 徹 順天堂大学, 医学部, 非常勤講師 (30420855)
工藤 孝広 順天堂大学, 医学部, 准教授 (90365601)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 食物アレルギー / 炎症性腸疾患 / ピロリ菌感染胃炎 / CXCL13 / 癌遺伝子 |
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| Outline of Final Research Achievements |
The aim of this study was to evaluate gene expression in the H. pylori-infected gastric mucosa of children using microarray and other analyses. Gastric mucosal samples were obtained from antrum and corpus from 24 patients (12 adults and 12 children) who had undergone endoscopic evaluation of chronic abdominal complaints and were examined. Six adult and pediatric patients with and six without (total, 24) H. pylori infection were enrolled.
The expression of inflammatory molecules was up-regulated in the H. pylori-infected gastric mucosa from both adults and children. The expression of OLFM4 was only up-regulated in adult patients, while that of PIM2, REG3A, LCN2 and CXCL 13 was equally up-regulated in the infected gastric mucosa of both.
Because several carcinogenic molecules are up-regulated in H.pylori-infected gastric mucosa even in childhood, early eradication therapy from childhood may be beneficial to decrease the incidence of gastric cancer.
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| Free Research Field |
小児消化器病学
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