Hypothermia attenuate brain damage by coordinating the function of glia

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09718
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Aichi Medical University
• Principal Investigator: Kakita Hiroki 愛知医科大学, 医学部, 講師 (40528949)
• Co-Investigator(Kenkyū-buntansha): 浅井 清文 名古屋市立大学, 大学院医学研究科, 教授 (70212462) ; 青山 峰芳 名古屋市立大学, 大学院薬学研究科, 教授 (70363918)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 新生児低酸素性虚血性脳症 / グリア / 低体温療法 / 一酸化窒素 / エリスロポエチン

Outline of Final Research Achievements

Hypothermia has been reported to be only effective therapy for neonatal hypoxic ischemic encephalopathy (HIE) . We performed the examination of microenviroment improvement of glial function control with hypothermia. We found hypothermia (32-34℃) decreased the expression of iNOS and inflammatory cytokine in cultured glia under hypoxic condition. Furthermore, erythropoietin having neuroprotective effect made clear that overexpression lasted by a low temperature state. We found that these protein expression adjustment by hypothermia decreased brain damage. This study might contribute to the development of an etiology of HIE which is still a poor prognosis and the cure.

Free Research Field

新生児学