Detection of the Intrinsic factors affecting on skin aging

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09747
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: University of the Ryukyus
• Principal Investigator: Takahashi Kenzo 琉球大学, 医学(系)研究科(研究院), 教授 (80291425)
• Research Collaborator: YAMAGUCHI Sayaka ; UTSUMI Daisuke ; OOKUBO Yuko ; OMINE Takuya
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 皮膚老化 / 中枢性老化 / 血清因子 / 並立結合 / 外因性老化 / 内因性老化

Outline of Final Research Achievements

Mouse skin aging was analyzed by comprehensively comparing gene expression on the skin of parallel mice between elderly and young mice as well as examining the skin of mice of each age, very old, old, young mice by RNA microarray. It was confirmed that genes belonging to early responsive gene including fos, fos-B, atf3, Jun, Jun-B, egr-1, are elevated along with aging, and it is also induced in young mice by serum factor transfer from old mice in parabiotic experiments. The expression of the PTGS2 gene was strongly enhanced as in the aging mice, similarly to the AP1 binding proteins. Thus, it was understood that some factor acts on epidermal keratinocytes, and results in the induction of COX 2 and Caspase 1, and the sustained chronic inflammation on the skin leads to the skin damage and aging.

Free Research Field

皮膚老化