An examination of novel typological approach in obsessive-compulsive spectrum disorders based on the findings regarding neurofunctional validity of the disorders.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09845
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hyogo Medical University
• Principal Investigator: Matsunaga Hisato 兵庫医科大学, 医学部, 教授 (20254394)
• Co-Investigator(Kenkyū-buntansha): 中嶋 章浩 兵庫医科大学, 医学部, 病院助手 (00739229) ; 向井 馨一郎 兵庫医科大学, 医学部, 病院助手 (70739218)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 強迫性障害 / 強迫スペクトラム障害 / 前頭葉機能検査 / 神経発達運動障害 / 治療抵抗性 / 目的志向性行動

Outline of Final Research Achievements

There is increasing evidence that obsessive-compulsive spectrum disorder (OCSD), especially obsessive-compulsive disorder (OCD) is a heterogeneous condition. For instance, recent factor analyses have provided cross-culturally consistent evidence that distinct OC symptom dimensions exist. These symptom dimensions have been differentially related to clinical features such as comorbidity. Our studies revealed that comorbid conditions might exert crucial effects on the prefrontal cortex activities along with long-term-treatment outcome of OCD.
To overcome the limitations of current pharmacotherapy for OCD, evaluations should focus on psychopathological features, such as comorbid disorders, or temporal transition of the brain mechanism according to the chronicity of OCD such as that from goal-directed to habitual nature of compulsions. The consideration of such cross-sectional and longitudinal heterogeneity of OCSD may be crucial to developing more effective treatments for the disorders.

Free Research Field

精神医学