Evaluation of pancreatic regeneration and islet number in pancreas and islet transplantation using Positron emission tomography

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09980
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Hospital Organization Chiba-East-Hospital
• Principal Investigator: OTSUKI KAZUNORI 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 研究員 (50399755)
• Co-Investigator(Kenkyū-buntansha): 圷 尚武 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 部長 (00344979) ; 丸山 通広 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, その他 (40399754) ; 西郷 健一 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 研究員 (60323424)
• Co-Investigator(Renkei-kenkyūsha): YOSHIKAWA kyosan 放射線医学総合研究所, 重粒子医科学センター, 画像診断室長 (00204793) ; SAGA tuneo 放射線医学総合研究所, 分子イメージングセンター, プログラムリーダー (40273445)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 11C-methionine PET / CT volumetry / 膵再生 / 生体膵ドナー

Outline of Final Research Achievements

To evaluate pancreas volumetric function (PVF) of the graft and live donor residual pancreas using 11C-methionine PET/CT in pancreas transplantation. Pre- and post-operative pancreas volume in donor was 29.3±7.5 and 38.0±7.9ml. Pre- and post-operative SUV in donor was 16.0±1.1and 16.9±5.0. PVF was elevated 1.38-times postoperatively. Assuming that the normal PVF is 100%, pre- and post-operative PVF in donor was 113% and 57%. Insulin independent PVF with brain-death and live donor was 70% and 24%. Insulin dependent PVF and graft failure was 12% and 0%.Pancreas regeneration was observed volumetric 38%, but functional 6% in donor pancreas.

Free Research Field

膵島移植