2017 Fiscal Year Final Research Report
Development of control method for hepatocellular carcinoma circulating tumor cells based on immunity-related gene polymorphism analysis
| Project/Area Number |
15K10166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 肝細胞癌 / 循環腫瘍細胞 / 門脈浸潤 / 転移 |
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| Outline of Final Research Achievements |
The purpose of this study was to develop a detection method of circulating tumor cells (CTC) specific to hepatocellular carcinoma and construct a system to accurately predict metastasis of hepatocellular carcinoma, and to establish a control method of CTC based on immune-related gene polymorphism analysis.
We established Glypican-3 (GPC3) positive CTC detection method using the magnetic cell separation system. Among 88 HCC resected cases, 53 cases (60.2%) were CTC positive and CTC positive (p<0.001) was an independent risk factor for portal vein invasion. CTC positive was also an independent risk factor for relapse-free survival (p=0.029). GPC3-CTC reflects portal vein invasion and postoperative recurrence and is a reasonable candidate as a target for postoperative adjuvant therapy.
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| Free Research Field |
肝胆膵外科学
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