The impact of transplantation of cardiomyocyte sheet derived from MHC homozygous induced pluripotent stem cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10212
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Osaka University
• Principal Investigator: Saito Shunsuke 大阪大学, 医学系研究科, 助教 (30600126)
• Co-Investigator(Kenkyū-buntansha): 宮川 繁 大阪大学, 医学系研究科, 特任教授(常勤) (70544237) ; 福嶌 五月 国立研究開発法人国立循環器病研究センター, 病院, 医長 (80596867) ; 秦 広樹 大阪大学, 医学系研究科, 講師 (80638198)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 心不全治療 / 再生医療 / 移植後拒絶反応 / iPS細胞

Outline of Final Research Achievements

MHC-matched transplantation using homozygous MHC haplotype iPSC-CMs displayed better engraftment and less immune-cell infiltration in the graft in MHC-mismatched transplantation. However, MHC-matched transplantation with single or no immune-suppressive drugs still induced a substantial host immune
response to the graft. Thus, the immunogenicity of allogeneic iPSC-CMs was reduced by MHC-matched transplantation although arequirement for appropriate immune suppression was retained for successful engraftment. Although MHC-homo-iPSCs are preferred to avoid immune rejection, MHC-mismatched iPSC-CMs can also induce comparable cardiac functional recovery at late follow-up, suggesting that MHC-mismatched iPSC-basedcardiac regenerative therapy with immunosuppressants may be a feasible option for treating heart failure in clinical setting.

Free Research Field

心臓血管外科