Investigation of the mechanism of osteolytic bone destruction in bone metastasis via tumor-associated carbohydrate antigen

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10427
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Hokkaido University
• Principal Investigator: Arai Ryuta 北海道大学, 大学病院, 助教 (40722509)
• Co-Investigator(Kenkyū-buntansha): 岩崎 倫政 北海道大学, 医学研究院, 教授 (30322803) ; 高畑 雅彦 北海道大学, 大学病院, 講師 (40374368)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 癌糖鎖抗原 / 糖認識分子 / 免疫受容体 / 破骨細胞 / 転移性骨腫瘍 / 骨巨細胞腫

Outline of Final Research Achievements

In bone metastasis of cancer, bone resorption by osteoclast plays an important role. Siglec 15 and sialyl Tn are involved in the differentiation of osteoclasts. We assumed that osteoclast differentiation by these molecules has been implicated in the formation of osteolytic bone metastases. A sialyl Tn-expressing breast cancer cell line was established and administered locally to the femur of nude mice. The differentiation of osteoclasts was not promoted and the formation of bone metastases was small in sialyl Tn-expressing breast cancer group, compared with control group. In vitro, sialyl Tn-expressing breast cancer cell was attenuated in cell adhesion ability. It was　suggested that the development of bone metastasis was attenuated in sialyl Tn expressing breast cancer cell group, because of decreased cell adhesion ability.

Free Research Field

骨軟部腫瘍