Effect of synovial mesenchymal stem cells for the rotator cuff healing

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10432
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MOCHIZUKI Tomoyuki 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (20436637)
• Co-Investigator(Kenkyū-buntansha): 関矢 一郎 東京医科歯科大学, 統合研究機構, 教授 (10345291) ; 二村 昭元 東京医科歯科大学, 大学院医歯学総合研究科, ジョイントリサーチ講座准教授 (40622098) ; 宗田 大 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50190864)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 再生医療 / 肩腱板断裂 / 滑膜幹細胞

Outline of Final Research Achievements

We performed a research making sure whether cells, harvested from membrane underling joint capsule, enhance rotator cuff healing. We used a rat model and firstly clarified that cells harvested from knee joint is superior to those from shoulder joint in proliferation potential. Secondly we made a rat model with rotator cuff tear on both shoulder and transplanted harvested cells torn site on one shoulder ,and no cells on the other side. We evaluated them on 2, 4 and 8 weeks after transplantation. The shoulders with transplanted cells showed superior to those with no cells in terms of bone-tendon healing in 8 weeks, and biomechanicaly had a higher ultimate load to failure than those without cell transplantation in 2 weeks.

Free Research Field

再生医療、肩関節疾患